Package: linpk 1.1.4
linpk: Generate Concentration-Time Profiles from Linear PK Systems
Generate concentration-time profiles from linear pharmacokinetic (PK) systems, possibly with first-order absorption or zero-order infusion, possibly with one or more peripheral compartments, and possibly under steady-state conditions. Single or multiple doses may be specified. Secondary (derived) PK parameters (e.g. Cmax, Ctrough, AUC, Tmax, half-life, etc.) are computed.
Authors:
linpk_1.1.4.tar.gz
linpk_1.1.4.zip(r-4.5)linpk_1.1.4.zip(r-4.4)linpk_1.1.4.zip(r-4.3)
linpk_1.1.4.tgz(r-4.4-any)linpk_1.1.4.tgz(r-4.3-any)
linpk_1.1.4.tar.gz(r-4.5-noble)linpk_1.1.4.tar.gz(r-4.4-noble)
linpk_1.1.4.tgz(r-4.4-emscripten)linpk_1.1.4.tgz(r-4.3-emscripten)
linpk.pdf |linpk.html✨
linpk/json (API)
NEWS
| # Install 'linpk' in R: |
| install.packages('linpk', repos = c('https://benjaminrich.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/benjaminrich/linpk/issues
Last updated 7 months agofrom:5bcfc4a44c. Checks:OK: 7. Indexed: yes.
| Target | Result | Date |
|---|---|---|
| Doc / Vignettes | OK | Nov 04 2024 |
| R-4.5-win | OK | Nov 04 2024 |
| R-4.5-linux | OK | Nov 04 2024 |
| R-4.4-win | OK | Nov 04 2024 |
| R-4.4-mac | OK | Nov 04 2024 |
| R-4.3-win | OK | Nov 04 2024 |
| R-4.3-mac | OK | Nov 04 2024 |
Exports:blockdiagcor2covDiagdose.framefinalstatefinaltimegenerateETAhalflifelinpkAppLTmatpkprofilesecondary
Dependencies:mvtnorm
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Coerce a 'pkprofile' to a 'data.frame' | as.data.frame.pkprofile |
| Construct a block-diagonal matrix. | blockdiag |
| Convert from standard deviation and correlation matrix to covariance matrix. | cor2cov |
| Diagonal Matrix | Diag |
| Get the doses from a PK profile. | dose.frame |
| Get the final state or time of a PK profile. | finalstate finaltime |
| Generate individual random effects from a multivariate normal distribution. | generateETA |
| Half-lives of a linear PK system. | halflife |
| Runs the interactive shiny app. | linpkApp |
| Construct a symmetric matrix from its lower triangle. | LTmat |
| Generate a concentration-time profile. | pkprofile pkprofile.default pkprofile.matrix |
| Continue an existing concentration-time profile. | pkprofile.pkprofile |
| Derive secondary PK parameters. | secondary |
