Introduction | Getting started | Dosing type | Multiple doses | Doses at steady state | Number of compartments | Secondary parameters | Half-lives | Other secondary parameters (Cmin, Cmax, AUC, ...) | Combining IV infusion with first-order absorption | Time-varying parameters | Shiny app | Limitations
Package: linpk 1.1.4
linpk: Generate Concentration-Time Profiles from Linear PK Systems
Generate concentration-time profiles from linear pharmacokinetic (PK) systems, possibly with first-order absorption or zero-order infusion, possibly with one or more peripheral compartments, and possibly under steady-state conditions. Single or multiple doses may be specified. Secondary (derived) PK parameters (e.g. Cmax, Ctrough, AUC, Tmax, half-life, etc.) are computed.
Authors:
linpk_1.1.4.tar.gz
linpk_1.1.4.zip(r-4.7-any)linpk_1.1.4.zip(r-4.6-any)linpk_1.1.4.zip(r-4.5-any)
linpk_1.1.4.tgz(r-4.6-any)linpk_1.1.4.tgz(r-4.5-any)
linpk_1.1.4.tar.gz(r-4.7-any)linpk_1.1.4.tar.gz(r-4.6-any)
linpk_1.1.4.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION |NEWS
card.svg |card.png
linpk/json (API)
| # Install 'linpk' in R: |
| install.packages('linpk', repos = c('https://benjaminrich.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/benjaminrich/linpk/issues
Last updated from:5bcfc4a44c. Checks:9 OK. Indexed: yes.
| Target | Result | Time | Files | Syslog |
|---|---|---|---|---|
| linux-devel | OK | 120 | ||
| source / vignettes | OK | 182 | ||
| linux-release | OK | 122 | ||
| macos-release | OK | 92 | ||
| macos-oldrel | OK | 115 | ||
| windows-devel | OK | 62 | ||
| windows-release | OK | 69 | ||
| windows-oldrel | OK | 49 | ||
| wasm-release | OK | 112 |
Exports:blockdiagcor2covDiagdose.framefinalstatefinaltimegenerateETAhalflifelinpkAppLTmatpkprofilesecondary
Dependencies:mvtnorm
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Coerce a 'pkprofile' to a 'data.frame' | as.data.frame.pkprofile |
| Construct a block-diagonal matrix. | blockdiag |
| Convert from standard deviation and correlation matrix to covariance matrix. | cor2cov |
| Diagonal Matrix | Diag |
| Get the doses from a PK profile. | dose.frame |
| Get the final state or time of a PK profile. | finalstate finaltime |
| Generate individual random effects from a multivariate normal distribution. | generateETA |
| Half-lives of a linear PK system. | halflife |
| Runs the interactive shiny app. | linpkApp |
| Construct a symmetric matrix from its lower triangle. | LTmat |
| Generate a concentration-time profile. | pkprofile pkprofile.default pkprofile.matrix |
| Continue an existing concentration-time profile. | pkprofile.pkprofile |
| Derive secondary PK parameters. | secondary |